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The excess AGEs could lead to non-enzymatic cross-linking of collagen, break the adhesion of osteoblasts to the extracellular matrix and leads to bone fragility ( −/− mice are mainly used to study atherosclerosis, but ApoE −/− mice can also be used to study osteoporosis
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[DOI] [PubMed] [Google Scholar] 23.López de Maturana R, Donnelly D
