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However, in people with type 2 diabetes a diminished antihyperglycemic effect from GIP has been observed while the insulinotropic effect of GLP-1 has been only slightly impaired
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For patients with established cardiovascular disease and obesity, the SELECT trial of semaglutide (Lincoff et al., NEJM 2023) showed a 20% reduction in major adverse cardiovascular events versus placebo
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